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    Hope For Psychosis Sufferers



    Summary: A new model of schizophrenia opens the door to a better understanding of, and therapeutic options for brain dysfunction that is at the root of psychosis.

    Source: Journal of Psychopharmacology.

    A research team of scientists from University of Otago have been working on ways to design schizophrenia symptoms in animal models. They have broken new grounds to enhance treatment of brain dysfunction which causes psychosis.

    Psychosis is a weakening characteristic of schizophrenia and, while current drugs treat it well, they have dreadful side effects which lead to poor quality of life for patients. Research which can identify specific mechanisms of the dysfunction can be helpful in finding more accurate drug targets for treatment, improving patient health conditions and quality of life.

    The researchers have recently made new discoveries, thanks to the Masters thesis work of Wayne Meighan, by combining a rat model of schizophrenia risk with a technique which allows a very sensitive screening for subjective internal state.

    The research team observed a critical aspect, that is, the dose of ketamine used causes schizophrenia-like psychosis in humans. They found that their model was reduced at differentiating the drug from saline, only at doses that cause psychosis in humans. According to the researchers, this means that the subjective internal state of these animal models is similar to the state developed in human psychosis.

    This opens up a way to model non-human symptoms that were formerly thought to be only measurable in humans, such as psychosis. This new finding may further improve our ability to pinpoint brain mechanisms of these symptoms and lead to more treatments.

    Published: Journal of Psychopharmacology.

    Contact: Wayne Meighan, Department of psychology, University of Otago.

    Details: Image source Istock


    Hi, I’m Aarti, My Psychoanalytical approach towards my clients is to empower them to better their lives through improving their relationship with themselves. I believe shame and guilt is a common barrier to change. I aim to guide my clients through re authoring their narratives where shame, guilt, and other problems have less power and take up less space.

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